Single-agent belantamab mafodotin (belamaf), a B-cell maturation antigen-targeting antibody-drug conjugate, achieved durable responses with a manageable safety profile in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM) in the Phase 2 DREAMM-2 trial (NCT03525678). The DREAMM-5 platform trial (208887; NCT04126200) is evaluating belamaf as combination therapy with other anticancer agents to determine if belamaf’s unique multimodal mechanism of action (MoA) is synergistic with MoAs of selected agents to further augment efficacy in RRMM. In this substudy, belamaf is combined with feladilimab (GSK3359609), an inducible co-stimulatory T-cell molecule (ICOS, CD278) agonist (aICOS).

Conclusion

In this preliminary analysis, belamaf combined with aICOS showed encouraging clinical activity along with a safety profile that was manageable through dose modifications in heavily pretreated patients with RRMM. Evaluating the efficacy and safety of belamaf + aICOS combination therapy as well as establishing the RP2D for the CE phase is ongoing in this substudy.

ASH 2021: Abstract 897