Our signature project’s mission is simple: Find a cure

For the world’s leading multiple myeloma experts, failure to find the cure for this cancer just isn’t an option. We’ve banded together the world’s brightest minds in research, oncology, and health studies to form the IMF’s Black Swan Research Initiative® (BSRI) – a leading-edge project that pits our scientists and leaders on the frontlines against myeloma. Together our mission is to find the first definitive cure for myeloma and help bridge the gap from long-term remission to cure.


black swanWhy “Black Swan”?

The Black Swan Research Initiative takes its name from the discovery of black swans in 1697, when it was assumed all swans were white. Just as people who had only seen white swans could not imagine the existence of black swans; until very recently, we could only imagine the possibility of finding a cure in our lifetimes. Through the Black Swan Research Initiative, we may soon see the first myeloma patients restored to a normal, healthy life, free of their cancer for the first time ever.

A Multinational Consortium of Myeloma Experts

Our experts are located all over the globe to assure we have a full team working in various environments in the search for a cure.






The Black Swan Research Initiative sponsors more than 25 projects around the world aimed at curing multiple myeloma. Among them....


The CESAR trial uses the combination of Kyprolis, Revlimid, and dexamethasone plus autologous stem-cell transplant to treat high-risk smoldering multiple myeloma. It applies:

  • Precise mininal residual disease (MRD) testing using next-generation flow cytometry (NGF)
  • Blood testing for routine monitoring


The ASCENT trial tests early intervention in high-risk smoldering multiple myeloma.


The iStopMM project identifies and treats multiple myeloma at the earliest signs of disease.


Studies are exploring long-term survival and hereditary risk factors in multiple myeloma.


Studies are:

  • Identifying mechanisms of the progression of multiple myeloma.
  • Testing DNA mutations in the blood. 
Linda Huguelet
Linda Huguelet, Chatanooga Multiple Myeloma Networking Group support leader
Diagnosed with myeloma in 2010
Just the thought that it's related to the word 'cure' is so exciting and something that I really didn't think I would see in my lifetime.
Be a Part of the Cure

Your donation allows us to continue to fund efforts to search for a cure. With your help, we are closer than ever.

group of researchers in a lab

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