Peripheral neuropathy (PN) is a change in feeling in the hands, fingers, legs, feet, toes, or lips, often described as pain, numbness, tingling, or burning. Report symptoms to your physician, who may adjust your myeloma treatment to help manage your PN symptoms. Multiple myeloma patients may experience peripheral neuropathy (PN) as a result of the disease itself or its treatments. Symptoms include:

  • Tingling
  • Burning pain
  • Muscle weakness
  • Sensitivity to touch
  • Prickling sensations
  • Sensation of cold in the feet

Types of neuropathy


  • Tingling, numbness, or pain in your hands or feet
  • Trouble hearing; ringing or buzzing in your ears
  • Weakness all over


  • Trouble fastening buttons.
  • Difficulty opening jars or feeling the shape of small objects with your hands.
  • Trouble walking

Treatments that cause neuropathy

Thalomid® (thalidomide), Velcade® (bortezomib), Ninlaro® (ixazomib), and Pomalyst® can all cause peripheral neuropathy; Revlimid® may make pre-existing neuropathy worse.

Managing the symptoms

Managing peripheral neuropathy will allow you to move more easily and safely, carry out your daily activities, and prevent unnecessary pain and discomfort. The following suggestions may help you:

  • Massage the affected area with cocoa butter.
  • Take B-complex vitamins.
  • Take folic acid supplements.
  • Take amino acid supplements.

If symptoms become more severe, your healthcare provider may recommend the following:

  • Pain medication or other medication for nerve pain relief
  • Stopping treatment for a period of time
  • Lowering the dose of treatment
  • Physical therapy

The International Myeloma Foundation medical and editorial content team

Comprised of leading medical researchers, hematologist, oncologists, oncology-certified nurses, medical editors, and medical journalists, our team has extensive knowledge of the multiple myeloma treatment and care landscape. Additionally, Dr. Brian G.M. Durie reviews and approves all medical content on this website.

Last Medical Review: August 1, 2019

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