Multiple myeloma drugs fall into various drug classes, including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs®), alkylating agents, corticosteroids, bisphosphonates, and monoclonal antibodies (MAbs).

Multiple Myeloma Drugs

In this section, medications are categorized according to their drug class. At the end of this list, there is a corresponding downloadable chart of these drugs.

Proteasome inhibitors (PI)

• NINLARO®  |  ixazomib  |  I
  Ninlaro (ixazomib) was approved by the U.S. Food and Drug Administration (FDA) in 2015 for the treatment of adult patients with myeloma who have received at least 1 prior therapy. Ninlaro is indicated in combination with Revlimid® (lenalidomide) and the steroid dexamethasone, a “triplet” (3-drug) combination known as “IRd.” Ninlaro is the third proteasome inhibitor approved by the FDA since 2003, and it is the first proteasome inhibitor that is taken orally by mouth.
• KYPROLIS®  |  carfilzomib  |  cfz, car, K
  Kyprolis (carfilzomib) is a proteasome inhibitor approved by the U.S. Food and Drug Administration (FDA) in 2012 for the treatment of relapsed or refractory myeloma. Kyprolis works by blocking the activity of enzyme complexes called proteasomes, which are important for maintaining balance within the cell and for regulating cell growth. Myeloma cells are more sensitive to proteasome inhibition than normal cells, so the myeloma cells die while normal cells are able to recover. Kyprolis is given by intravenous (IV) infusion at a doctor’s office, hospital, or clinic.
• VELCADE®  |  bortezomib  |  btz, bor, V
  Velcade (bortezomib) is an anti-cancer agent available for injection into a vein (intravenously or IV) or under the skin (subcutaneously). Velcade is indicated for the treatment of newly diagnosed and relapsed or refractory myeloma.

Immunomodulators (IMiD)

• POMALYST®  |  pomalidomide  |  pom, P
  Pomalyst (pomalidomide) is an oral treatment for multiple myeloma indicated, in combination with dexamethasone, for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor.
• REVLIMID®  |  lenalidomide  |  len, R
  Revlimid (lenalidomide), an immunomodulatory drug (IMiD®), is the first oral medication that was developed for treatment of multiple myeloma. It is used in the newly diagnosed, maintenance therapy, and relapsed and/or refractory settings.
• THALOMID®  |  thalidomide  |  thal, T
  Thalomid (thalidomide) is an oral immunomodulatory drug, an agent that can modify or regulate the immune system. It has both anti-inflammatory and anti-cancer activities. Thalidomide was first used to treat multiple myeloma in 1997.

Monoclonal antibodies (MAb)

• DARZALEX®  |  daratumumab  |  dara
  Darzalex (daratumumab) is the first FDA-approved monoclonal antibody that targets the CD38 protein on the surface of myeloma cells. It is approved for adult patients with myeloma in multiple disease settings, from the newly diagnosed to the relapsed/refractory. Darzalex is administered intravenously.
• DARZALEX FASPRO® |  daratumumab and hyaluronidase-fihj
  Darzalex Faspro (daratumumab and hyaluronidase-fihj) is a new formulation of Darzalex that is given as an abdominal injection under the skin. It is approved for adult patients with multiple myeloma in multiple disease settings from the newly diagnosed to the relapsed/refractory.  .
• EMPLICITI®  |  elotuzumab  |  elo, E
  Empliciti (elotuzumab) is a monoclonal antibody. It is an intravenously infused prescription medicine used to treat multiple myeloma in combination with the medicines Revlimid® (lenalidomide) and dexamethasone, in people who have received one to three prior treatments for their disease. It is also approved for use in combination with Pomalyst® and dexamethasone in patients with myeloma who have received at least 2 prior therapies including Revlimid and a proteasome inhibitor.
• SARCLISA®  |  isatuximab-ifrc
  Sarclisa (isatuximab-ifrc) is a novel anti-CD38 monoclonal antibody. It is given as an intravenous infusion every week for 4 weeks, then every 2 weeks. It is administered as part of a three-drug regimen known as Isa-Pd, or Sarclisa plus Pomalyst® and dexemthasone. 

B-cell maturation antigens (BCMA)

• ABECMA®  |  idecabtagene vicleucel  |  ide-cel
  Abecma (idecabtagene vicleucel), a personalized immune cell therapy delivered as a one-time infusion, is approved for use in adult patients with relapsed and refractory myeloma who have had four or more prior lines of therapy that include three major drug classes, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody.

• BLENREP®  |  belantamab mafodotin-blmf  |  bela, belamaf
  In November 2022, GSK announced it has initiated the process for withdrawal of the U.S. marketing authorization for Blenrep following the request of the FDA. Blenrep is no longer a choice in the care of myeloma patients, but some patients may be continuing care on Blenrep. Previously, this BCMA-directed antibody-drug conjugate (ADC) was indicated for the treatment of adult patients with relapsed or refractory myeloma who have received at least 4 prior therapies including an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent.

• CARVYKTI™  |  ciltacabtagene autoleucel  |  cilta-cel
  Carvykti (ciltacabtagene autoleucel, cilta-cel) a personalized immune cell therapy delivered as a one-time infusion, is approved for use in adult patients with relapsed or refractory multiple myeloma, who have had four or more prior lines of therapy that include three major drug classes, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody. Carvykti is manufactured for each individual patient using the patient’s own white blood cells (T cells)

• TECVAYLI™| (teclistamab-cqyv)
  Tecvayli (teclistamab-cqyv), is indicated for adult patients with relapsed or refractory myeloma who have had at least four prior lines of therapy, including a protea­some inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. Tecvayli is the first-in-class bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. The “off-the-shelf” availability of Tecvayli makes it easier to access treatment. Unlike CAR T-cell therapy that requires several weeks for the collection, engineering, and manufacturing of the patient’s T cells, Tecvayli engages the patient’s T cells to kill myeloma cells directly after injection. 

Nuclear export inhibitor

• XPOVIO®  |  selinexor
  Xpovio (selinexor) is a selective inhibitor of nuclear export (SINE) compound, the first medication in this drug class to be approved by the U.S. Food and Drug Administration (FDA) for the treatment of myeloma. In 2019, Xpovio was granted accelerated approval for use in combination with dexamethasone (Xd) for relapsed and/or refractory myeloma after at least 4 prior therapies. In 2020, Xpovio was approved in combination with Velcade® (bortezo­mib) + dexamethasone (XVd) for myeloma patients who have received at least 1 prior therapy.

Alkylating agents

• ALKERAN®, ALPHALAN®  | melphalan, mel, M
  Alkeran (melphalan) is a chemotherapy drug commonly used in treating multiple myeloma. In the U.S., melphalan is most commonly used in the treatment of MM as the conditioning agent in autologous stem cell transplant. It is given as an intravenous infusion (IV) at a high dose to ablate (wipe out the cells within) the bone marrow, where myeloma grows, the day before the patient's own hematopoietic (blood-making) stem cells are given back to restore bone marrow function. It is also used, most commonly outside the U.S., as an oral agent to treat myeloma in combination with Velcade® and prednisone (VMP), and in combination with thalidomide and prednisone (MPT).
   
• Cyclophosphamide |  CTX, Cy, C
  Cyclophosphamide was first approved by the U.S. Food and Drug Administration (FDA) in 1959, and is still widely used to treat multiple myeloma, as well as many other types of cancer and autoimmune diseases. As a first-line therapy, it is most commonly given orally in combination with Velcade (bortezomib) and dexamethasone (CyBorD or VCd). Cyclophosphamide is also given orally at relapse in combination with Revlimid® and dexamethasone (CRd) or Pomalyst® and dexamethasone (CPd). A Cyclophosphamide infusion, or intravenous (IV) Cyclophosphamide, can also be used as part of the stem cell harvesting process in combination with colony stimulating factors.

Corticosteroids

• DECADRON®  |  dexamethasone  |  D, d, dex, DXM
  Dexamethasone (which is sometimes called “dex” for short) is also known by the brand names Decadron®, Dexasone®, Diodex®, Hexadrol®, and Maxidex®. It is one of the most frequently used medications in the treatment of multiple myeloma
• DELTASONE®  |  prednisone  |  pred, P
  Prednisone belongs to a class of drugs known as corticosteroids. It decreases your immune system's response to various diseases to reduce symptoms such as swelling and allergic-type reactions.
• MEDROL®  |  methylprednisolone
  Methylprednisolone is used to decrease your immune system's response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. 

Bone-modifying agents

• XGEVA®  |  denosumab
  Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.
• ZOMETA®  |  zoledronic acid  |  zol
  Zoledronic acid is also used with cancer chemotherapy to treat bone problems that may occur with multiple myeloma and other types of cancer (such as breast, lung) that have spread to the bones.
• AREDIA®  |  pamidronate  |  pmd
  Pamidronate is used to treat high blood calcium levels and certain bone problems (bone metastases/lesions) that may occur with some types of cancer.

Download Chart of Approved Multiple Myeloma Drugs

 

Guide to Myeloma Drug Names

Multiple myeloma treatments have evolved over the last thirty years. Since 2009 alone, more than a dozen new treatments have been developed for the disease. This table provides a comprehensive list of many of the drugs that have been used to treat myeloma through time. You may want to reference this list if you are a patient researching clinical trials or if you are a myeloma researcher.

GENERIC NAME	BRAND NAME	ORIGINAL NAME
afuresertib		GSK2110183
belantamab mafodotin	Blenrep®	bela, belamaf
bendamustine	Treanda®	SDX-105
bortezomib	Velcade®	PS-341
carfilzomib	Kyprolis®	PR-171
ciltacabtagene autoleucel	Carvykti™	JNJ-682845281
dabrafenib	Tafinlar®
daratumumab	Darzalex®	CD38 mAb
dasatinib	Sprycel®	BMS-354825
denosumab	XGEVA®	AMG-162, osteoprotegerin
dinaciclib		SCH 727965
durvalumab		MED14736
eltrombopag	Promacta®
elotuzumab	Empliciti®	HuLuc63
everolimus	Afinitor®	LY317615
filanesib		ARRY-520
Ibrutinib	Imbruvica®	PCI-32765
Idecabtagene vicleucel (ide-cel)	Abecma®	bb2121
indatuximab ravtansine		BT062
ipilumumab	Yervoy®
ixazomib	Ninlaro®	MLN9708
lenalidomide	Revlimid®	CC-5013
lirilumab		IPH-2102, BMS-986015
marizomib		NPI-0052, salinosporamide
masitinib		AB1010
melphalan	Alkeran®
nelfinavir	Viracept®
nivolumab	Opdivo®	BMS-936558
oprozomib		ONX-0912
palbociclib	Ibrance®	PD 0332991
pamidronate	Aredia®
panobinostat	Farydak®	LBH589
pegylated liposomal doxorubicin	Doxil®
pembrolizumab	Keytruda®	MK-3475-013
pidilizumab		CT-011
plerixafor	Mozobil®	AMD3100
plitidepsin	Aplidin®
pomalidomide	Pomalyst®	CC-4047
quisinostat		JNJ26481585
ricolinostat		ACY-1215
romidepsin	Istodax®	FK228, depsipeptide
selinexor	Xpovio®	KPT-330
sirolimus	Rapamune®	rapamycin, AY 22989
sonidegib	Odomzo®	LDE225, erismodegib
sotatercept		ACE-011
temsirolimus	Torisel®	CCI-779
thalidomide	Thalomid®
trametinib	Mekinist®	GSK11202
ulocuplumab		BMS-936564
urelumab		BMS-663513
venetoclax	Venclexta®	ABT-199
vorinostat	Zolinza®	SAHA
zoledronic acid, zoledronate	Zometa®

 

What's Next?