What is the STaMINA study?

STaMINA was a phase III trial comparing the long-term outcomes among 758 myeloma patients undergoing single autologous transplant with or without consolidation therapy versus tandem autologous transplant with lenalidomide maintenance. 

In this video:

Dr. Parameswaran Hari, Professor of Hematology at the Medical College of Wisconsin, discusses the long-term follow-up of the STaMINA study.

Conclusion:

Long term outcomes are similar using ITT, but as treated analysis suggested a progression-free survival benefit for patients who had undergone tandem autologous hematopoietic cell transplant, driven mainly by patients with high-risk multiple myeloma. Lenalidomide discontinuation even at 38 mo was associated with inferior progression-free survival.

Clinical trial information: NCT02322320

PARAMESWARAN HARI, MD

Parameswaran Hari, MD, MRCP, MS, is the Armand J. Quick/William F. Stapp Professor of Hematology at the Medical College of Wisconsin. He serves as Chief in the Division of Hematology and Oncology in the Department of Medicine. His main areas of focus include allogeneic hematopoietic stem cell transplantation, plasma cell disorders, multiple myeloma, amyloidosis, and other monoclonal gammopathies.