Idecabtagene vicleucel (ide-cel; bb2121), a BCMA-targeted CAR T-cell therapy, in patients with relapsed and refractory multiple myeloma (RRMM): Initial KarMMa results
What is ide-cel?
Ide-cel is a B-cell maturation antigen (BCMA) targeted CAR T-cell therapy. It demonstrates promising tolerability and efficacy in relapsed refractory multiple myeloma (RRMM) patients.
In this video:
Dr. Nikhil Munshi (Dana-Farber Cancer Institute — Boston) explains that ide-cel demonstrated deep, durable responses in heavily pretreated RRMM patients. He discusses why outcomes are poor in triple-class exposed RRMM patients who progress on immunomodulatory agents (IMiDs), proteasome inhibitors (PIs), and CD38 antibodies (mAbs).
Efficacy and safety reflected prior reports and support a favorable ide-cel clinical benefit-risk profile across the target dose range.
Clinical trial information: NCT03361748
NIKHIL MUNSHI, MD
Dr. Munshi received his MD from Maharaja Sayjirao University, India, in 1984. He completed his postgraduate training in Internal Medicine at SSG Hospital and Maharaja Sayjirao University, followed by fellowships at Johns Hopkins Oncology Center and Indiana University Medical Center. In 2001, he joined Dana-Farber Cancer Institute and is currently the Director of Basic and Correlative Science, Jerome Lipper Multiple Myeloma Center.