Dr. Amrita Krishnan on a Phase I Teclistimab Study
What is the background of this study?
BCMA-targeted immunotherapies offer considerable promise for relapsed/refractory multiple myeloma (MM). Teclistamab (JNJ-64007957) is a BCMA × CD3 bispecific IgG4 antibody that redirects CD3+ T cells to BCMA-expressing multiple myeloma cells.
In this video:
Dr. Amrita Krishnan (City of Hope, Duarte, CA, USA) explains that this study presents updated results of patients treated at the recommended phase II dose in the first-in-human phase I study of teclistamab. Eligible patients had multiple myeloma and were relapsed, refractory or intolerant to established therapies. This study sought to identify the phase II dose (part 1) and characterize safety and tolerability of teclistamab at the phase II dose (part 2)
Conclusions:
Teclistamab at the phase II dose (weekly 1500 µg/kg subcutaneous) was well-tolerated and showed encouraging efficacy with durable, deepening responses, supporting further investigation as monotherapy and in combination with other agents. With the extended exposure profile at the phase II dose and delayed and low-grade cytokine release syndrome observed with subcutaneous (SC) administration, alternative SC dosing strategies are being explored.
Clinical Trial Information: NCT03145181
