The impact of body mass index on the risk of early progression of smoldering multiple myeloma to symptomatic myeloma
Wilson I. Gonsalves, MD
Rochester, MN, USA
Background: Human adipocytes can contribute directly to the in vitro growth and progression of multiple myeloma (MM) cell lines. Clinically, an elevated body mass index (BMI) has been associated with an increased risk of MGUS and a shorter time to progression (TTP) of MGUS to MM. However, the impact of BMI on the risk of early progression to MM from a more advanced plasma cell disorder such as smoldering MM (SMM) remains unknown.
Conclusions: SMM pts with an elevated BMI appear to have a higher risk of early progression to MM than those with a normal BMI. This study provides evidence of a potentially modifiable risk factor for the progression of SMM to MM and warrants confirmation in larger studies.
Author(s): Wilson I. Gonsalves, S. Vincent Rajkumar, Angela Dispenzieri, Martha Lacy, Francis Buadi, David Dingli, Ronald S. Go, Prashant Kapoor, Suzanne R. Hayman, John Anthony Lust, Nelson Leung, Stephen J. Russell, Steven R. Zeldenrust, Yi Lin, Yi Lisa Hwa, Taxiarchis Kourelis, Robert A. Kyle, Morie A. Gertz, Shaji Kumar
ABOUT WILSON I. GONSALVES, MD
Dr. Wilson I. Gonsalves, M.D., is a Senior Associate Consultant, Division of Hematology, Department of Internal Medicine, at the Mayo Clinic in Rochester, Minnesota. His main areas of focus include plasma cell metabolism, supportive care in plasma cell disorders, and population-based outcomes in plasma cell disorders. View Dr. Wilson I. Gonsalves full biography here.