International Myeloma Working Group molecular classification of multiple myeloma: spotlight review

The goals of this paper are the following:

  • to biologically classify multiple myeloma “based on known genetic subtypes with associated clinico-pathological associations”
  • “to establish the prognostic value of known and new genetic factors for MM outcome, including the information generated through genomic tools”
  • “to provide a framework for evaluation of new markers capable of serving as predictive for efficacy of novel therapeutics”

A general breakdown of myeloma cell categorization is as follows:

  • Hyperdiploid cells (more inactive clinical features)
    • Trisomies
    • Deletion of chromosomes 13 and 17
    • Abnormalities of chromosome 1
      • 1p deletion and q1 amplification
  • Non-hyperdiploid cells (more intensive clinical features)
    • IgH translocations
      • t(11;14)
      • (q13;q32)
      • t(4;14)
      • (p16;q32)
      • (q32;q23)


R Fonseca, PL Bergsagel, J Drach, J. Shaughnessy, N Gutierrez, AK Stewart, G Morgan, B Van Ness, M Chesi, S Minvielle, A Neri, B Barlogie, WM Kuehl, P Liebisch, F Davies, S Chen-Kiang, BGM Durie, R Carrasco, Orhan Sezer, Tony Reiman, Linda Pilarski and H Avet-Loiseau

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