International Myeloma Working Group molecular classification of multiple myeloma: spotlight review
The goals of this paper are the following:
- to biologically classify multiple myeloma “based on known genetic subtypes with associated clinico-pathological associations”
- “to establish the prognostic value of known and new genetic factors for MM outcome, including the information generated through genomic tools”
- “to provide a framework for evaluation of new markers capable of serving as predictive for efficacy of novel therapeutics”
A general breakdown of myeloma cell categorization is as follows:
- Hyperdiploid cells (more inactive clinical features)
- Trisomies
- Deletion of chromosomes 13 and 17
- Abnormalities of chromosome 1
- 1p deletion and q1 amplification
- Non-hyperdiploid cells (more intensive clinical features)
- IgH translocations
- t(11;14)
- (q13;q32)
- t(4;14)
- (p16;q32)
- (q32;q23)
- IgH translocations
Authors:
R Fonseca, PL Bergsagel, J Drach, J. Shaughnessy, N Gutierrez, AK Stewart, G Morgan, B Van Ness, M Chesi, S Minvielle, A Neri, B Barlogie, WM Kuehl, P Liebisch, F Davies, S Chen-Kiang, BGM Durie, R Carrasco, Orhan Sezer, Tony Reiman, Linda Pilarski and H Avet-Loiseau
Click here to view article: