International Staging System for Multiple Myeloma

This research focuses on unifying a multiple myeloma staging system around the world called the International Staging System (ISS). Information was taken from 10,750 myeloma patients previously untreated from North America, Asia, and Europe. The results of testing three different assessments for staging showed that using serum beta2-micoglobulin (SB2M) and serum albumin was the best approach for a three-stage classification system. The new founded ISS system proved to be better than the Durie-Salmon staging system, patients younger and older than 65 years old, and in patients undergoing standard therapy for treatment or autotransplant.


Antonio Palumbo, Hervé Avet-Loiseau, Stefania Oliva, Henk M. Lokhorst, Hartmut Goldschmidt, Laura Rosinol, Paul Richardson, Simona Caltagirone, Juan José Lahuerta, Thierry Facon, Sara Bringhen, Francesca Gay, Michel Attal, Roberto Passera, Andrew Spencer, Massimo Offidani, Shaji Kumar, Pellegrino Musto, Sagar Lonial, Maria T. Petrucci, Robert Z. Orlowski, Elena Zamagni, Gareth Morgan, Meletios A. Dimopoulos, Brian G.M. Durie, Kenneth C. Anderson, Pieter Sonneveld, Jésus San Miguel, Michele Cavo, S. Vincent Rajkumar and Philippe Moreau

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