Dr. Saad Usmani on the DREAMM-9 Trial

What is the DREAMM-9 trial?
The DREAMM-9 trial is a phase III study of bortezomib, lenalidomide, and dexamethasone (VRd) as the standard of care for transplant-eligible and transplant-ineligible newly diagnosed multiple myeloma patients. Yet, relapse is usually inevitable.

In this video:
Dr. Saad Usmani explains that the median progression-free survival (PFS) is around three years for patients with transplant-ineligible newly diagnosed multiple myeloma. Also, with each relapse, the duration of response (DoR) diminishes, highlighting the need for novel, effective, targeted agents.

Conclusion:
Single-agent belantamab mafodotin is a first-in-class B-cell maturation antigen–binding, humanized, afucosylated, monoclonal immunoconjugate, showing deep and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma. Preclinical work suggests belantamab mafodotin plus bortezomib or lenalidomide enhances anti-myeloma activity. Therefore, studying clinical activity of belantamab mafodotin in combination with these agents is warranted.

Clinical trial information: NCT04091126 (https://www.clinicaltrials.gov/ct2/show/NCT04091126)

SAAD USMANI, MD, FACP

Dr. Usmani joined Levine Cancer Institute as the Director of Plasma Cell Disorder program and the Director of Clinical Research in Hematologic Malignancies at Levine Cancer Institute/Carolinas Healthcare System. He is a specialist in Hematology, Medical Oncology and Bone Marrow Transplantation.