Updates from ICARIA-MM, a phase 3 study of isatuximab (Isa) plus pomalidomide and low-dose dexamethasone (Pd) versus Pd in relapsed and refractory multiple myeloma

ICARIA Multiple Myeloma Phase III Study

Background of the study:

Isatuximab (Isa) is an approved monoclonal antibody that binds to a specific epitope on the CD38 receptor. The Phase 3 ICARIA-MM study (NCT02990338) demonstrated significantly improved progression-free survival (PFS) with Isa plus pomalidomide and dexamethasone (Isa-Pd) versus pomalidomide and dexamethasone alone (Pd) (P= 0.001) and a manageable safety profile (Attal M, et al. Lancet 2019;394:2096-2107). Here we report updated ICARIA results.

In this video:

Dr. Paul Richardson (Dana-Farber Cancer Institute, Boston, MA, USA) discusses the updated results from ICARIA-MM.


Isa-Pd demonstrates a significant improvement in time to next treatment and PFS2 compared with Pd. A strong trend in overall survival (OS) benefit was also seen in the Isa-Pd arm, with approximately 7 months improvement in median OS. The overall safety profile remains unchanged from prior analyses. Funding: Sanofi. 

Clinical trial information: NCT02990338

ASCO 2021, ICARIA, pomalidomide, isatuximab
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Source URL: https://www.myeloma.org/videos/updates-icaria-mm-phase-3-study-isatuximab-isa-plus-pomalidomide-low-dose-dexamethasone-pd