Dr. Hartmut Goldschmidt on the CARTITUDE-1 Study

What is the background of the study?

Patients with relapsed/refractory multiple myeloma (RRMM) who are triple-class exposed to immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs) and anti-CD38 monoclonal antibodies (MoABs) have few treatment options available and poor outcomes (Gandhi et al., Leukemia, 2019). Ciltacabtagene autoleucel (cilta-cel), a chimeric antigen receptor T-cell (CAR-T) therapy, is studied in CARTITUDE-1, an open-label, single arm phase 1b/2 clinical trial assessing safety and efficacy of cilta-cel in adult patients with triple-class exposed relapsed/refractory multiple myeloma (RRMM). In absence of a comparator arm in CARTITUDE-1, comparison of trial outcomes versus an external cohort of similar patients allows to quantify clinical benefits relative to treatments used in current clinical practice.

In this video:

Dr. Hartmut Goldschmidt, MD (Universität Heidelberg, Heidelberg, Germany) compares the outcomes of the CARTITUDE-1 study versus real world clinical practice.

Conclusions:

Comparative analyses using PLD, adjusting for differences in patient characteristics between both cohorts, shows that cilta-cel patients had significantly longer overall survival and time to next treatment compared to patients treated with therapies used in current clinical practice in Germany. These findings highlight cilta-cel’s potential as an effective treatment option to address currently unmet treatment needs in triple-class exposed patients with RRMM.