The impact of body mass index on the risk of early progression of smoldering multiple myeloma to symptomatic myeloma

Wilson I. Gonsalves, MD
Mayo Clinic
Rochester, MN, USA

Background: Human adipocytes can contribute directly to the in vitro growth and progression of multiple myeloma (MM) cell lines. Clinically, an elevated body mass index (BMI) has been associated with an increased risk of MGUS and a shorter time to progression (TTP) of MGUS to MM. However, the impact of BMI on the risk of early progression to MM from a more advanced plasma cell disorder such as smoldering MM (SMM) remains unknown.

Conclusions: SMM pts with an elevated BMI appear to have a higher risk of early progression to MM than those with a normal BMI. This study provides evidence of a potentially modifiable risk factor for the progression of SMM to MM and warrants confirmation in larger studies.

Author(s): Wilson I. Gonsalves, S. Vincent Rajkumar, Angela Dispenzieri, Martha Lacy, Francis Buadi, David Dingli, Ronald S. Go, Prashant Kapoor, Suzanne R. Hayman, John Anthony Lust, Nelson Leung, Stephen J. Russell, Steven R. Zeldenrust, Yi Lin, Yi Lisa Hwa, Taxiarchis Kourelis, Robert A. Kyle, Morie A. Gertz, Shaji Kumar