How is high-risk smoldering multiple myeloma diagnosed?


In this video, Dr. Brian G.M. Durie explains that active myeloma is diagnosed if a patient has CRAB features and myeloma-defining events. He also sheds light on a new set of criteria for high-risk smoldering multiple myeloma, known as the 2/20/20 rule.

Talk with your doctor to assess if you have high-risk smoldering multiple myeloma.

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IMF Chairman and Co-Founder Brian G.M. Durie, MD welcomes your questions about the latest myeloma treatments, research, controversies and quality of life issues. If you have a question you think might be of interest to the myeloma community, please send to!

For questions of a specific personal nature, please call the IMF InfoLine coordinators at 800.452.2873 or email them at