Thalidomide is classified as an immunomodulatory agent, which means it affects the levels of certain chemicals in the body that control the activity of cells.
Celgene's Patient Support Coordinators assist patients and healthcare providers to navigate the challenges of reimbursement, provide information about co-pay assistance, and answer general questions about Revlimid.
Celgene has developed a new program called Fast Track for First Prescription™ to help eligible patients receive their first prescriptions for a Celgene product quickly and efficiently. Fast Track is an optional service of Celgene Patient Support that facilitates communication between doctors, patients, insurance providers, risk management programs, pharmacies, and co-pay foundations. A Celgene Patient Support coordinator will ensure that “all the ducks are in a row” as quickly as possible, and remove the hurdles to accessing that first cycle of medication. To be eligible, patients must be receiving their first prescription of either Thalomid or Revlimid, must have documented proof of insurance, and must be registered in a Celgene risk management program and have a valid authorization number. For more information on the program, call the IMF InfoLine at 800-452-2873.
Possible Side Effects
Thalidomide often causes feelings of drowsiness. These methods may help relieve this side effect:
Taking thalidomide at bedtime
- Avoiding use of other drugs that may cause drowsiness while taking thalidomide
- At the discretion of a doctor or nurse, taking other drugs to help alleviate drowsiness
- Avoiding alcohol.
Situations in which drowsiness may be a problem should be avoided. Mental and physical abilities needed to perform dangerous tasks, such as driving a car, may be impaired.
Impairment of the nerves in the extremities (hands, arms, legs, feet) is known as peripheral neuropathy. This side effect can be mild, causing tingling in the hands and feet; more rarely, it can be severe and painful. It typically occurs after a long period of taking thalidomide, but it can sometimes occur sooner. These strategies may help alleviate symptoms of peripheral neuropathy:
- Walking and other forms of exercising
- Avoiding tight shoes and socks with elastic
- At the discretion of a doctor, reducing the dose of thalidomide
- At the discretion of a doctor, taking additional medications
A physician should be notified if any symptoms of peripheral neuropathy occur. If side effects are severe, thalidomide therapy may need to be stopped altogether.
Dizziness may occur during treatment with thalidomide. Sitting up and waiting a few minutes before standing or getting out of bed may help reduce dizziness.
Constipation may occur during treatment with thalidomide; however, constipation is rarely severe. Prevention is the key to management.
These strategies may help alleviate constipation:
- Drinking at least 8 glasses of fluid daily
- Adding plenty of dietary fiber every morning, such as prune juice, apple juice, and bran
- At the recommendation of a doctor or nurse, taking stool softeners and laxatives.
If constipation becomes severe, the dose of thalidomide may be lowered or temporarily discontinued.
In some cases, a rash may develop while taking thalidomide. A mild rash (red or discolored skin, with or without raised bumps) usually begins on the trunk and spreads to the arms and legs. Mild rashes may be relieved in the following ways:
- At the recommendation of a doctor or nurse, taking antihistamines and topical corticosteroids
- To alleviate dry skin, use oatmeal soap, calendula cream, cocoa butter cream, Eucerin® cream, or Acid Mantle® cream.
Thalidomide can sometimes cause a decrease in white blood cells. This condition is called leukopenia. Because of this possibility, blood tests need to be done regularly. If the white blood cell count becomes too low, the dose of thalidomide may have to be changed or the treatment may need to be interrupted.