Myeloma Minute: Positive STORM Trial Results

Positive Top-Line Phase IIb STORM Results Reported, with Plans for Development Path of Selinexor for the Treatment of Multiple Myeloma

Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, announced the initiation of the STORM study (Selinexor Treatment of Refractory Myeloma) on September 6, 2016. STORM is a multi-center, single-arm Phase II study of selinexor (KPT-330) in heavily-pretreated patients with quad-refractory multiple myeloma. Selinexor, the company's lead, novel, oral Selective Inhibitor of Nuclear Export / SINE™ compound, will be evaluated in combination with low-dose dexamethasone in multiple myeloma patients whose disease was refractory to treatment with bortezomib (Velcade®), lenalidomide (Revlimid®), carfilzomib (Kyprolis®) and pomalidomide (Pomalyst®). The first cohort will enroll approximately 80 patients at about 30 sites, primarily inthe United States, with ~25% of the patients also having received treatment with an anti-CD38 monoclonal antibody such as daratumumab. Depending on the results from this initial cohort, the trial may be expanded to include additional patients. Data from an expanded trial may support an accelerated approval of selinexor in refractory multiple myeloma. Selinexor received orphan drug designation from the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for multiple myeloma.

 

Ray Romano to Host IMF 10th Annual Comedy Celebration – Nov. 5

The IMF’s annual Comedy Celebration will take place on Saturday, November 5 at the Wilshire Ebell Theatre. Actor and comedian Ray Romano returns as “Everybody’s Most-Loved Host,” with featured performers Bill Burr, Jeff Garlin, Dom Irrera, Larry Miller, Kevin Nealon, JB Smoove, and Fred Willard. Proceeds from the event benefit the Peter Boyle Research Fund and support the Black Swan Research Initiative® (BSRI). Renowned actor Peter Boyle died in 2006 after a four-year battle with myeloma. In celebration of the event’s 10th anniversary, the event will honor Loraine Alterman Boyle for her extraordinary work as the event chair over the past 10 years. Since the annual Comedy Celebration began in 2007, the event has raised more than $5 million to support myeloma research. The evening will include a pre-show cocktail reception and silent auction, and a post-show party featuring a live swing band and dancing for VIP ticket holders. Tickets are now on sale HERE.

 

 

Catch a Replay of Last Week's Living Well with Myeloma Teleconference

If you were not able to tune into last week’s teleconference, “CAR T-Cell Therapy: What Patients and Caregivers Need to Know,” an audio replay is available HERE. Led by IMF’s Medical Liaison Dr. Rafat Abonour (Indiana University – Simon Cancer Center) and Dr. Edward Stadtmauer (University of Pennsylvania), this teleconference discussed the results thus far of such new agents as Darzalex™ (daratumumab) and Empliciti™ (elotuzumab), and for which combinations these agents are best suited. However, the main focus was on CAR T-cells, (chimeric antigen receptor T-cells), which are part of a class of cancer therapies known as immunotherapies. With CAR T-cell therapy, a patient’s T-cells are harvested and genetically reengineered to become better able to recognize and attack myeloma. The altered T-cells are then reinfused into the body with the hope of fighting the disease. Detailed slides illustrate these mechanisms HERE.

 

Dance and Dine to Support the IMF

In November 2013, at the age of 36, Matt Blennau was diagnosed with multiple myeloma. Matt, an active coach, husband, and father, underwent a clinical trial, multiple rounds of chemotherapy, and a stem cell transplant. Today he lives with multiple myeloma, enduring rounds of chemo every other week. Inspired by his fortitude, his sister Debbie reached out to the IMF to organize “A Mission for Matt,” a dinner and dance. This FUNdraiser takes place from 7 p.m. to 11 p.m. on Saturday, October 1, 2016 at the Knights of Columbus Council - 186 Jericho Turnpike in Mineola, New York. Register or donate HERE.

Guys and Gears: All Rides Welcome!

On Sunday, October 2nd at 1:00 PM CT in Overland Park, Kansas, car owners can strut their rides at Guys and Gears. Bring your car to showcase and “compete.” At 4:00 PM CT trophies will be awarded to cars that meet the following distinctions: Best Muscle Car, Best Engine, Most Unique, Best Painted, Best Engine Rev Up, Best All Original, Best Classic, Best Custom, Longest Distance Traveled, and Best of Show. So bring your souped-up motor car or your eccentric jalopy to 7365 W. 97th St. in Overland Park, Kansas for this event that will benefit the International Myeloma Foundation. To register, contact Karen Foster at kcfosterz@hotmail.com. Pre-registration is $10 or $20 (which earns you a free T-shirt!) Registration day of event is $15 and does not include a T-shirt. To learn more or donate, click HERE.


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