Myelosuppression, Bone Disease, and Acute Renal Failure: Evidence-Based Recommendations for Oncologic Emergencies

Background: Oncologic emergencies associated with multiple myeloma include myelosuppression (anemia, neutropenia, and thrombocytopenia), bone-related emergencies, and acute renal failure.

Objectives: This article reviews the pathophysiology of these multiple myeloma-associated oncology emergencies and provides a framework for assessment and effective intervention.

Methods: A comprehensive review of the levels of evidence, focusing on assessment, diagnosis, comorbidities, treatment, ongoing monitoring, and patient education, are presented to support the plan of care for at-risk patients.

Findings: Attention to signs and symptoms is the foundation for preventing these emergencies or managing additional escalation of symptoms.


Kevin Brigle, Amy Pierre, Elizabeth Finley-Oliver, Beth Faiman, Joseph D. Tariman, Teresa Miceli, and the International Myeloma Foundation Nurse Leadership Board

CJON 2017, 21(5), 60-76 DOI: 10.1188/17.CJON.S5.60-76

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