International Staging System (ISS) for Multiple Myeloma
|Stage||VALUES (β2M = Serum β2 microglobulin; ALB = serum albumin|
|I||β2M < 3.5 mg/L; ALB ≥ 3.5 g/dL|
|II||β2M < 3.5 mg/L; ALB ≥ 3.5 g/dL; or β2M 3.5 – 5.5 mg/L|
|III||β2M > 5.5 mg/L|
Revised International Staging System (R-ISS)
Serum β2 microglobulin < 3.5 mg/l
|II||Not R-ISS stage I or III|
Serum β2 microglobulin ≥ 5.5 mg/L and either
If you are a newly diagnosed myeloma patient, learn when and if to begin treatment. Also, if you have undergone an induction therapy, learn about maintenance therapy and other new interventions.
The International Myeloma Foundation medical and editorial content team
Comprised of leading medical researchers, hematologist, oncologists, oncology-certified nurses, medical editors, and medical journalists, our team has extensive knowledge of the multiple myeloma treatment and care landscape. Additionally, Dr. Brian G.M. Durie reviews and approves all medical content on this website.
Last Medical Review: August 1, 2019